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Mitochondrial peptide dossier

How should the human MOTS-c sequence and molecular form be recorded?

A research-standard dossier for the 16-residue human MOTS-c sequence, mitochondrial coding context, terminal state, mass convention, and salt-form separation.

Reviewed by Peptide Harbor editorial reviewUpdated 2026-08-03Educational research-data guidance

Answer first

A human MOTS-c record should state the 16-residue sequence MRWQEMGYIFYPRKLR and the molecular form used for its formula and mass. The sequence originates from a short open reading frame within mitochondrial 12S rRNA, while acetate or TFA material forms need separate composition records rather than silently changing the free-peptide ledger.

Reviewed Chemical LedgerMOTS-c (human)
Molecular form representedFree human 16-residue peptide represented by PubChem CID 176489569
Molecular formula
C101H152N28O22S2
Average molecular weight
2174.6 g/mol average molecular weight
Exact mass
2174.1110958 Da
Reviewed peptide designationH-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Sequence representationIncludes stated terminal and modification notation
MRWQEMGYIFYPRKLR
Known Aliases / Code Names:MOTS-cMOTS-c (human)Mitochondrial open reading frame of the 12S rRNA-c

Field-level sources

PubChem CID 176489569: MOTS-c Peptide

National Library of Medicine / PubChem · accessed 2026-08-03

Supports: name, molecularForm, formula, weight, exactMass, peptideDesignation, aliases

The mitochondrial-derived peptide MOTS-c

Cell Metabolism / PubMed · accessed 2026-08-03

Supports: sequence

Where this framework helps

  • Human MOTS-c identity and sequence-reference planning
  • Separating free-peptide and counter-ion forms
  • Designing intact-mass and sequence-level evidence requests

Limits to keep visible

  • The mitochondrial coding context does not verify a synthesized project sample.
  • The PubChem free-peptide values must not be reused for an undeclared salt form.
  • Disease, exercise-performance, dosing, and human-use content is excluded.
01

Fix the species and sequence

The discovery paper identifies human MOTS-c as a 16-amino-acid peptide encoded within mitochondrial 12S rRNA. Species context belongs in the record because homologous sequences are not automatically interchangeable.

02

Keep salt forms outside the free-peptide calculation

PubChem contains separate records associated with TFA or acetate wording. A data packet should record the supplied form and obtain composition evidence instead of adding a counter-ion assumption to the free-peptide mass.

03

Match evidence depth to the identity question

An intact-mass result can support expected-form agreement; sequence-level localization requires a suitable fragment workflow; salt and water accounting requires separate measurements.

Primary and official sources

References used for this page

Visible FAQ

Questions research teams ask

How many residues are in human MOTS-c?

The reviewed human sequence contains 16 residues: MRWQEMGYIFYPRKLR.

Does an acetate label change the peptide backbone?

It does not change the backbone sequence, but it changes the material composition record and may change the mass basis used for a weighed sample.

Can mitochondrial origin establish synthetic material identity?

No. It explains the biological sequence source; the synthesized material still needs its own analytical evidence and declared molecular form.